Epithalon

What It Is

A synthetic tetrapeptide (four amino acids: Ala-Glu-Asp-Gly) based on epithalamin, a compound naturally produced by the pineal gland. Epithalon is studied primarily for its effects on telomerase, the enzyme responsible for maintaining telomere length.

How It Works

Epithalon reaches the cellular environment

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Activates telomerase enzyme expression

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Telomerase adds protective sequences to chromosome ends

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Telomere shortening is slowed, extending replicative capacity

What Researchers Study It For

Telomere length maintenance

Telomerase activation mechanisms

Cellular senescence and replicative lifespan

Pineal gland function and circadian regulation

Common Research Protocols

Epithalon is supplied as a lyophilized powder and reconstituted with bacteriostatic water. In preclinical studies, it is typically administered via subcutaneous injection. Research by Khavinson et al. demonstrated that epithalon induced telomerase activity in human somatic cells and increased mean telomere length.

Community Interest Areas

Epithalon has attracted strong interest in the longevity research community for its direct action on telomerase — the enzyme most closely associated with biological aging at the chromosomal level. It is often studied alongside NAD+ in multi-compound longevity protocols that target both energy metabolism and genomic stability.

4 Amino Acids Synthetic tetrapeptide based on pineal gland epithalamin

Peer-Reviewed Demonstrated telomerase activation in human somatic cells (Khavinson et al.)

For research purposes only. Not intended for consumption, clinical application, or diagnostic use.

What It Is

How It Works

What Researchers Study It For

Common Research Protocols

Community Interest Areas

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