MOTS-c

What It Is

A 16-amino-acid peptide encoded within the mitochondrial genome itself — making it one of the few known signaling molecules produced directly by mitochondria. MOTS-c acts as a retrograde signal from the mitochondria to the nucleus, influencing how the cell responds to metabolic stress.

How It Works

MOTS-c is produced by mitochondrial DNA

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Activates AMPK, the cellular energy sensor

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Enhances glucose uptake and fatty acid oxidation

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Restores metabolic homeostasis under stress

What Researchers Study It For

Metabolic regulation and glucose homeostasis

Exercise mimetic pathways

Insulin sensitivity and metabolic stress

Mitochondria-to-nucleus communication

Common Research Protocols

MOTS-c is typically supplied as a lyophilized peptide and reconstituted with bacteriostatic water for subcutaneous injection. Research has demonstrated that MOTS-c levels in circulating plasma decline with age, paralleling the decline in metabolic function.

Community Interest Areas

MOTS-c has generated particular interest as a potential "exercise mimetic" — a compound that activates some of the same metabolic pathways as physical exercise. Researchers are exploring its role in AMPK signaling, body composition, and age-related metabolic decline.

16 Amino Acids Encoded directly by the mitochondrial genome

Peer-Reviewed Studied as an exercise mimetic via AMPK activation pathways

For research purposes only. Not intended for consumption, clinical application, or diagnostic use.

What It Is

How It Works

What Researchers Study It For

Common Research Protocols

Community Interest Areas

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