PT-141

What It Is

A synthetic cyclic peptide heptapeptide and analog of α-MSH that acts as a non-selective agonist of melanocortin receptors, with notable activity at MC4R. Studied in preclinical and clinical literature for its central nervous system effects on behavioral pathways.

How It Works

PT-141 reaches central melanocortin pathways

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Binds MC4R (and other melanocortin receptors)

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Hypothalamic neural circuits are activated

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Centrally mediated behavioral pathways are studied

What Researchers Study It For

MC4R receptor pharmacology studies

Hypothalamic signaling investigations

Centrally acting neuropeptide modeling

Cyclic peptide pharmacokinetic research

Common Research Protocols

In published research, PT-141 has been administered subcutaneously and intranasally, with dosing in the low-milligram range and time-to-onset measured across multiple-hour windows.

Community Interest Areas

The neuroendocrinology community has been particularly drawn to PT-141 because it acts upstream of vascular mechanisms — engaging central melanocortin circuits rather than peripheral hemodynamics. This positions it as a research probe for studying the hypothalamic neural basis of behavioral states distinct from receptor families targeted by other classes of compounds.

MC4R Non-selective melanocortin receptor agonist

Central Engages hypothalamic circuits upstream of vascular mechanisms

For research purposes only. Not intended for consumption, clinical application, or diagnostic use.

What It Is

How It Works

What Researchers Study It For

Common Research Protocols

Community Interest Areas

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